The following is a list of alternates for the 2022 Massachusetts Open Championship.
To review Mass Golf’s alternate policy in full, please click here. Any questions about the alternate policy can be directed to Kevin Eldridge via email (keldridge@massgolf.org) or phone (774-430-9103).
| Rank | Name | Affiliation | Qualifying Site | Date Added |
| 1 | Dylan Evans | Granite Links Golf Club | New Seabury | 5/26 |
| 2 | Charlie Campbell | Cape Cod National Golf Club | Gardner GC | 5/26 |
| 3 | Mike Hersey | Harmon Golf | Kernwood CC | 6/2 |
| 4 | Thomas Harrison | Thorny Lea Golf Club | LeBaron Hills CC | 6/2 |
| 5 | Jack Prue | Lebaron Hills Country Club | LeBaron Hills CC | n/a |
| 6 | Carey Bina | King of Prussia, PA | LeBaron Hills CC | 6/6 |
| 7 | Dan Fanion | Springfield Country Club | Marlborough CC | 6/7 |
| 8 | Phil Smith | Vesper Country Club | LeBaron Hills CC | 6/7 |
| 9 | Timothy Hegarty | Briarcliff Manor, NY | CC of Pittsfield | 6/7 |
| 10 | Christian Lightner | Oakley Country Club | Kernwood CC | n/a |
| 11 | Danny Frodigh | Dedham Country and Polo Club | Kernwood CC | 6/7 |
| 12 | Nick Marcoaldi | Fort Myers, FL | Gardner GC | n/a |
| 13 | Michael Souliotis | Haverhill Golf & Country Club | Kernwood CC | 6/8 |
| 14 | Nick Drago | Plymouth Country Club | New Seabury | |
| 15 | Jack O’Donnell | Boston Golf Club | Kernwood CC | |
| 16 | Matt Adams | Presidents Golf Course | LeBaron Hills CC | |
| 17 | Patrick Bean | Oak Hill Country Club | Gardner GC | |
| 18 | Trevor Lopez | Winchester CC | CC of Pittsfield | |
| 19 | Arthur Ouimet | Manchester, CT | Marlborough CC | |
| 20 | Trevor Drew | Long Meadow Golf Club | Kernwood CC | |
| 21 | Kyle Alexander | Worcester Country Club | Marlborough CC | |
| 22 | Patrick Dempsey | Sharon Country Club | LeBaron Hills CC | |
| 23 | Cooper Griffin | Woodland Golf Club | LeBaron Hills CC | |
| 24 | Jared Huggins | Mount Pleasant Golf Club | Gardner GC | |
| 25 | Sean Connor | South Shore Country Club | Kernwood CC | |
| 26 | Jack Walter | Woodland Golf Club | New Seabury | |
| 27 | Luca Greco | Montreal, QC | Marlborough CC | |
| 28 | Eric Cormier | Maplegate Country Club | Marlborough CC | |
| 29 | Ryan Downes | GreatHorse | CC of Pittsfield | |
| 30 | Patrick Ginnity | Northern Spy Country Club | Gardner GC | |
| 31 | Christopher Barone | The Cape Club of Sharon | LeBaron Hills CC | |
| 32 | Brandon Valvano | Franklin Lakes, NJ | Marlborough CC | |
| 33 | Riley Rohlfs | Nashawtuc Country Club | Gardner GC | |
| 34 | Alex Jeffers | Woodland Golf Club | Kernwood CC | |
| 35 | Marc Issler | Jupiter, FL | CC of Pittsfield | |
| 36 | Tommy Parker | George Wright Golf Course | LeBaron Hills CC | |
| 37 | Clifford Lindholm | Montclair, NJ | LeBaron Hills CC | |
| 38 | Colin Brennan | Indian Ridge Country Club | Gardner GC | |
| 39 | Clark McMahon | Kernwood Country Club | Kernwood CC |
